Biyomedikal Mühendisliği

GBE 406 | Ders Tanıtım Bilgileri

Dersin Adı

Gene Control and Epigenetics

Kodu	Yarıyıl	Teori (saat/hafta)	Uygulama/Lab (saat/hafta)	Yerel Kredi	AKTS
GBE 406	FALL	2	2	3	6

Ön-Koşul(lar)	Yok
Dersin Dili	English
Dersin Türü	ELECTIVE_COURSE
Dersin Düzeyi	Lisans
Dersin Veriliş Şekli	Face-To-Face
Dersin Öğretim Yöntem ve Teknikleri	Discussion Group work Problem solving Case study Q&A Lecture/Presentation
Ulusal Meslek Sınıflandırma Kodu	-
Dersin Koordinatörü	Doç. Dr. Cihangir Yandım
Öğretim Eleman(lar)ı	Doç. Dr. Cihangir Yandım
Yardımcı(ları)	-

Dersin Amacı

The aim of this course is to teach the effects of gene control and epigenetic mechanisms on pluripotency and reprogramming, their role in cell division and cell differentiation, and how errors in these mechanisms lead to diseases. It is also aimed to give techniques related to gene control and measurement of epigenetic mechanisms.

Öğrenme Çıktıları

Bu dersi başarıyla tamamlayabilen öğrenciler;

Ad	Açıklama	PC Alt	* Katkı Düzeyi
Ad	Açıklama	PC Alt	1	2	3	4	5
LO1	Will be able to explain the concept of epigenetics and its multi-layered mechanisms,			X
LO2	Will be able to discuss epigenetic mechanisms through specific examples,			X
LO3	Will be able to explain silencing methods at the transcription level,			X
LO4	Will be able to choose techniques that can analyze the relationship between epigenetics and human diseases,			X
LO5	Will be able to interpret the results of methods measuring epigenetic markers.		X

Ders Tanımı

This course explains the gene control mechanisms that affect development and deteriorate in disease. The course covers epigenetic markers and related techniques to identify differences in gene regulation.

Dersin İlişkili Olduğu Sürdürülebilir Kalkınma Amaçları

Dersin Kategorisi	Temel Ders
	Uzmanlık/Alan Dersleri	X
	Destek Dersleri
	İletişim ve Yönetim Becerileri Dersleri
	Aktarılabilir Beceri Dersleri

HAFTALIK KONULAR VE İLGİLİ ÖN HAZIRLIK ÇALIŞMALARI

Hafta	Konular	Ön Hazırlık	Öğrenme Çıktısı
1	Introduction	Epigenetics, Cold Spring Harbor Laboratory Press, 2015 - Chapter 1	LO1
2	Circuit elements of a gene	Molecular Biology of the Cell 6th edition, Garland-Norton, 2015 - Chapter 1	LO1
3	RNA polymerase and fundamentals of gene control	Molecular Biology of the Cell 6th edition, Garland-Norton, 2015. -Chapter 6. Transcription Regulation at the Core: Similarities Among Bacterial, Archaeal, and Eukaryotic RNA Polymerases, Decker and Hinton, Annual Reviews, 2013.	LO3
4	Chromatin and chromsome architecture	Molecular Biology of the Cell 6th edition, Garland-Norton, 2015. - Chapter 4.	LO1
5	Histone modifications	Epigenetics, Cold Spring Harbor Laboratory Press, 2015.- Chapters 4,5,6. Lateral Thinking: How Histone Modifications Regulate Gene Expression, Lawrence et al., Trends in Genetics, 2016.	b844e03f-e191-4b1f-982c-37cd80d63801
6	Dynamics of chromatin remodeling	Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes, Clapier et al. , Nature Reviews, 2017.	LO4
7	Chromatin balance and gene insulation	Heterochromatin effects in Friedreich's ataxia and sexual dimorphism. C. Yandım, PhD Thesis, Imperial College London, 2012. Gene Regulation and Epigenetics in Friedreich's ataxia. Yandım et al. J of Neurochem., 2013.	LO2
8	Midterm		-
9	Nuclear architecture	Biogenesis and function of nuclear bodies, Mao et al, Trends in Genetics, 2011.	LO1
10	DNA methylation and epigenetic reprogramming	Principles of DNA methylation and their implications for biology and medicine, Dor and Cedar., Lancet, 2018.	LO4
11	RNA interference	Strategies for silencing human disease using RNA interference, Kim and Rossi, Nature Reviews, 2007.	LO3
12	Epigenetic memory	Mechanisms of epigenetic memory, D'Urso and Brickner, Trends in Genetics, 2014.	LO5
13	Induced pluripotency	Epigenetics, Cold Spring Harbor Laboratory Press, 2015. - Chapter 28	LO2
14	Epigenetics and human disease	Epigenetics, Cold Spring Harbor Laboratory Press, 2015- Chapter 33.	LO5
15	Review		-
16	Final exam		-

Ders Kitabı

Human Molecular Genetics by Strachan and Read (2018) Garland Science. ISBN: 0815345895

Önerilen Okumalar/Materyaller

Chromosome Architecture and Genome Organization by Bernardi (2015) PLoS One
Heterochromatin effects in Friedrich's ataxia and sexual dimorphism (2012) PhD Thesis by C. Yandım
Transcription Regulation at the Core: similarities among bacterial archaeal and eukaryotic RNA polymerases by Decker and Hinton (2013) Annual Reviews
Lateral thinking: how histone modifications regulate gene expression by Lawrence et al. (2016) Trends in Genetics
Principles of DNA methylation and their implications for biology and medicine by Dor and Cedar (2018) The Lancet
Molecular mechanisms of RNA interference by Wilson and Doudna (2013) Annual Reviews.

DEĞERLENDİRME ÖLÇÜTLERİ

Yarıyıl Aktiviteleri	Sayı	Katkı Payı %	LO1	LO2	LO3	LO4	LO5
Ödev	4	40		X	X	X	X
Ara Sınav	1	30	X	X			X
Final Sınavı	1	30	X		X	X
Toplam	6	100

AKTS / İŞ YÜKÜ TABLOSU

Yarıyıl Aktiviteleri	Sayı	Süre (Saat)	İş Yükü
Katılım	-	-	-
Teorik Ders Saati	16	2	32
Laboratuvar / Uygulama Ders Saati	16	2	32
Sınıf Dışı Ders Çalışması	14	2	28
Arazi Çalışması	-	-	-
Küçük Sınav / Stüdyo Kritiği	-	-	-
Portfolyo	-	-	-
Ödev	4	5	20
Sunum / Jüri Önünde Sunum	-	-	-
Proje	-	-	-
Seminer/Çalıştay	-	-	-
Sözlü Sınav	-	-	-
Ara Sınavlar	1	34	34
Final Sınavı	1	34	34
		Toplam	180