Biyomedikal Mühendisliği

GBE 355 | Ders Tanıtım Bilgileri

Dersin Adı

Microbial Biofilms

Kodu	Yarıyıl	Teori (saat/hafta)	Uygulama/Lab (saat/hafta)	Yerel Kredi	AKTS
GBE 355	SPRING	3	0	3	5

Ön-Koşul(lar)	Yok
Dersin Dili	English
Dersin Türü	ELECTIVE_COURSE
Dersin Düzeyi	Lisans
Dersin Veriliş Şekli	Face to Face
Dersin Öğretim Yöntem ve Teknikleri	Lecture/Presentation & Discussion & Grup Study & Q&A
Ulusal Meslek Sınıflandırma Kodu	-
Dersin Koordinatörü	Dr. Öğr. Üyesi Fatma Pınar Gördesli Duatepe
Öğretim Eleman(lar)ı	Dr. Öğr. Üyesi Fatma Pınar Gördesli Duatepe
Yardımcı(ları)	-

Dersin Amacı

The aim of this course is to explain the formation and dispersion processes of microbial biofilms and the environmental signals and signaling networks regulating these processes, to provide information about biofilm infections, biofouling, and the strategies to combat biofilms.

Öğrenme Çıktıları

Bu dersi başarıyla tamamlayabilen öğrenciler;

Ad	Açıklama	PC Alt	* Katkı Düzeyi
Ad	Açıklama	PC Alt	1	2	3	4	5
LO1	Describe the life cycle of microbial biofilms,			X
LO2	Explain the environmental signals and signaling networks regulating the formation and dispersion of microbial biofilms,			X
LO3	Compare the methods that trigger the dispersion of biofilms,			X
LO4	Define the role of microbial biofilms in chronic and implant-associated infections,			X
LO5	Discuss the strategies developed for the control and prevention of biofilm formation on biotic and abiotic surfaces.					X

Ders Tanımı

This course covers the formation of microbial biofilms, the structure and functions of the extracellular polymeric substance synthesized in biofilm formation, environmental signals and intracellular and intercellular signaling networks regulating the biofilm formation and dispersion processes, and biofouling on surfaces, chronic infections and implant-associated infections caused by biofilms. In addition, this course also provides information on the current strategies developed to combat biofilms.

Dersin İlişkili Olduğu Sürdürülebilir Kalkınma Amaçları

Dersin Kategorisi	Temel Ders
	Uzmanlık/Alan Dersleri	X
	Destek Dersleri
	İletişim ve Yönetim Becerileri Dersleri
	Aktarılabilir Beceri Dersleri

HAFTALIK KONULAR VE İLGİLİ ÖN HAZIRLIK ÇALIŞMALARI

Hafta	Konular	Ön Hazırlık	Öğrenme Çıktısı
1	Introduction to biofilms	Staffan Kjelleberg, Michael Givskov. The Biofilm Mode of Life: Mechanisms and Adaptations, 1st Edition. Horizon Bioscience, 2007. Chapter 1	LO1
2	Mechanisms of bacterial adhesion, biofilm formation, biofilm life cycle	Staffan Kjelleberg, Michael Givskov. The Biofilm Mode of Life: Mechanisms and Adaptations, 1st Edition. Horizon Bioscience, 2007. Chapter 2 and Chapter 3	LO1
3	Functions and components of extracellular polymeric biofilm matrix (EPS)	Staffan Kjelleberg, Michael Givskov. The Biofilm Mode of Life: Mechanisms and Adaptations, 1st Edition. Horizon Bioscience, 2007. Chapter 4	LO1
4	Regulatory signaling networks of biofilm formation and dispersion, and cyclic diguanylate monophosphate (c-di GMP)	Staffan Kjelleberg, Michael Givskov. The Biofilm Mode of Life: Mechanisms and Adaptations, 1st Edition. Horizon Bioscience, 2007. Chapter 5	LO2
5	Regulatory signaling networks of biofilm formation and dispersion, and quorum sensing	Staffan Kjelleberg, Michael Givskov. The Biofilm Mode of Life: Mechanisms and Adaptations, 1st Edition. Horizon Bioscience, 2007. Chapter 6 Rina Rani Ray, Moupriya Nag, Dibyajit Lahiri. Biofilm-Mediated Diseases: Causes and Controls, 1st Edition. Springer Nature, 2021. Chapter 2	LO2
6	Biofilm dispersion	Staffan Kjelleberg, Michael Givskov. The Biofilm Mode of Life: Mechanisms and Adaptations, 1st Edition. Horizon Bioscience, 2007. Chapter 9	LO3
7	Biofilms and biofouling	Rina Rani Ray, Moupriya Nag, Dibyajit Lahiri. Biofilm-Mediated Diseases: Causes and Controls, 1st Edition. Springer Nature, 2021. Chapter 4	LO3
8	Midterm Exam		-
9	Biofilms and chronic infections	Rina Rani Ray, Moupriya Nag, Dibyajit Lahiri. Biofilm-Mediated Diseases: Causes and Controls, 1st Edition. Springer Nature, 2021. Chapter 4 and Chapter 5	LO4
10	Biofilms and implant-associated infections	Rina Rani Ray, Moupriya Nag, Dibyajit Lahiri. Biofilm-Mediated Diseases: Causes and Controls, 1st Edition. Springer Nature, 2021. Chapter 7	LO4
11	Biofilms and antimicrobial resistance	Rina Rani Ray, Moupriya Nag, Dibyajit Lahiri. Biofilm-Mediated Diseases: Causes and Controls, 1st Edition. Springer Nature, 2021. Chapter 8	LO4
12	Control and inhibition of biofilm formation, strategies that trigger biofilm dispersion	Rina Rani Ray, Moupriya Nag, Dibyajit Lahiri. Biofilm-Mediated Diseases: Causes and Controls, 1st Edition. Springer Nature, 2021. Chapter 9 and Chapter 10	LO5
13	Novel treatment strategies for biofilm infections	Rina Rani Ray, Moupriya Nag, Dibyajit Lahiri. Biofilm-Mediated Diseases: Causes and Controls, 1st Edition. Springer Nature, 2021. Chapter 10	LO5
14	Student Presentations		-
15	Semester Review		-
16	Final Exam		-

Ders Kitabı	-
Önerilen Okumalar/Materyaller	-

DEĞERLENDİRME ÖLÇÜTLERİ

Yarıyıl Aktiviteleri	Sayı	Katkı Payı %	LO1	LO2	LO3	LO4	LO5
Ödev	1	15			X	X	X
Sunum / Jüri Önünde Sunum	1	20					X
Ara Sınav	1	25	X	X	X
Final Sınavı	1	40	X	X	X	X
Toplam	4	100

AKTS / İŞ YÜKÜ TABLOSU

Yarıyıl Aktiviteleri	Sayı	Süre (Saat)	İş Yükü
Katılım	-	-	-
Teorik Ders Saati	16	3	48
Laboratuvar / Uygulama Ders Saati	-	-	-
Sınıf Dışı Ders Çalışması	14	2	28
Arazi Çalışması	-	-	-
Küçük Sınav / Stüdyo Kritiği	-	-	-
Portfolyo	-	-	-
Ödev	1	15	15
Sunum / Jüri Önünde Sunum	1	18	18
Proje	-	-	-
Seminer/Çalıştay	-	-	-
Sözlü Sınav	-	-	-
Ara Sınavlar	1	18	18
Final Sınavı	1	23	23
		Toplam	150