Biyomedikal Mühendisliği

GBE 340 | Ders Tanıtım Bilgileri

Dersin Adı

Cell Death Mechanisms

Kodu	Yarıyıl	Teori (saat/hafta)	Uygulama/Lab (saat/hafta)	Yerel Kredi	AKTS
GBE 340	SPRING	3	0	3	5

Ön-Koşul(lar)	Yok
Dersin Dili	English
Dersin Türü	ELECTIVE_COURSE
Dersin Düzeyi	Lisans
Dersin Veriliş Şekli	Face to Face
Dersin Öğretim Yöntem ve Teknikleri	Discussion Group Work Q&A Lecture / Presentation
Ulusal Meslek Sınıflandırma Kodu	-
Dersin Koordinatörü	Prof. Dr. Zeynep Fırtına Karagonlar
Öğretim Eleman(lar)ı	Dr. Öğr. Üyesi Gizem Ayna Duran
Yardımcı(ları)	-

Dersin Amacı

This course will focus on understanding the basics of conventional as well as unconventional cell death mechanisms and their roles in development, physiology and pathology. It will cover a broad range of topics in cell death field including apoptosis, autophagy, necrosis, necroptosis, lysosome-dependent cell death, entosis, anoikis, ferroptosis, pyroptosis, anastasis, mitotic death and immunogenic cell death.

Öğrenme Çıktıları

Bu dersi başarıyla tamamlayabilen öğrenciler;

Ad	Açıklama	PC Alt	* Katkı Düzeyi
Ad	Açıklama	PC Alt	1	2	3	4	5
LO1	Explain the basic principles of cell death mechanisms and apply these principles to solve current problems in the field				X
LO2	Explain the methods used to analyse cell death mechanisms				X
LO3	Model cell death mechanisms, and will be able to report this model individually and present it orally				X
LO4	Explain the role of cell death mechanisms in embryonic development and how dysregulation of these mechanisms can lead to pathological conditions such as cancer and neurodegenerative diseases				X

Ders Tanımı

This course covers the description of molecular mechanisms of cell death including apoptosis, autophagy, necrosis, necroptosis, lysosome-dependent cell death, entosis, anoikis, ferroptosis, pyroptosis, anastasis, mitotic death and immunogenic cell death.

Dersin İlişkili Olduğu Sürdürülebilir Kalkınma Amaçları

Dersin Kategorisi	Temel Ders
	Uzmanlık/Alan Dersleri	X
	Destek Dersleri
	İletişim ve Yönetim Becerileri Dersleri
	Aktarılabilir Beceri Dersleri

HAFTALIK KONULAR VE İLGİLİ ÖN HAZIRLIK ÇALIŞMALARI

Hafta	Konular	Ön Hazırlık	Öğrenme Çıktısı
1	Introduction to cell death modalities	Alberts et.al. 6th Edition. Chapter 18.	LO1
2	Non-programmed cell death: Necrosis	Alberts et.al. 6th Edition. Chapter 18.	LO1
3	Programmed apoptotic cell death: Apoptotic Cell Death and Anoikis	Galluzzi, Lorenzo et al. “Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018” Cell death and differentiation vol. 25,3 (2018): 486-541.	LO1
4	Intrinsic and Extrinsic Apoptotic Cell Death	Galluzzi, Lorenzo et al. “Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018” Cell death and differentiation vol. 25,3 (2018): 486-541.	LO2
5	Apoptotic Cell Death Detection Methods	Hugh J. M. Brady. Apoptosis Methods and Protocols. Humana Press 2004. https://doi.org/10.1385/1592598129	LO2
6	Programmed non-apoptotic cell death: Vacuole based	Galluzzi, L et al. “Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012” Cell death and differentiation vol. 19,1 (2011): 107-20.	LO2
7	Programmed non-apoptotic cell death: Mitochondria and iron based	Kroemer, G et al. “Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009” Cell death and differentiation vol. 16,1 (2008): 3-11.	LO2
8	Midterm		-
9	Programmed non-apoptotic cell death: Vacuole based: Immunogenic cell death and others	Galluzzi, Lorenzo et al. “Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018” Cell death and differentiation vol. 25,3 (2018): 486-541.	LO3
10	Programmed cell death in prokaryotes	Galluzzi, Lorenzo et al. “Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018” Cell death and differentiation vol. 25,3 (2018): 486-541.	LO3
11	Clinical aspects of cell death	Douglas R Green. Means to an End: Apoptosis and Other Cell Death Mechanisms. Cold Spring Harbor Laboratory Press. 2017. Galluzzi, Lorenzo et al. “Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018” Cell death and differentiation vol. 25,3 (2018): 486-541.	LO4
12	Non-lethal processes such as anastasis, mitotic destruction and cellular senescence	Hochman A. Programmed cell death in prokaryotes. Crit Rev Microbiol. 1997;23(3):207-14.	LO4
13	Cell-in-cell death (entosis, cannibalism and imperitosis)	Galluzzi L, Buqué A, Kepp O, Zitvogel L, Kroemer G. Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol. 2017 Feb;17(2):97-111. doi: 10.1038/nri.2016.107. Epub 2016 Oct 17.	LO4
14	Review of the semester		-
15	Review of the semester		-
16	Final		-

Ders Kitabı	Bruce Alberts- Alexander- Johnson Julian -Lewis David -Morgan- Martin Raff- Keith Roberts- Peter Walter. Molecular Biology of the Cell. Sixth Edition. Chapter 18 – Cell Death. Garland Science 2014: New York and Abingdon UK. Douglas R Green. Means to an End: Apoptosis and Other Cell Death Mechanisms. Cold Spring Harbor Laboratory Press. 2017.
Önerilen Okumalar/Materyaller	-

DEĞERLENDİRME ÖLÇÜTLERİ

Yarıyıl Aktiviteleri	Sayı	Katkı Payı %	LO1	LO2	LO3	LO4
Ödev	1	25			X	X
Sunum / Jüri Önünde Sunum	1	25		X	X
Ara Sınav	1	20	X	X
Final Sınavı	1	30	X	X		X
Toplam	4	100

AKTS / İŞ YÜKÜ TABLOSU

Yarıyıl Aktiviteleri	Sayı	Süre (Saat)	İş Yükü
Katılım	-	-	-
Teorik Ders Saati	16	3	48
Laboratuvar / Uygulama Ders Saati	-	-	-
Sınıf Dışı Ders Çalışması	16	2	32
Arazi Çalışması	-	-	-
Küçük Sınav / Stüdyo Kritiği	-	-	-
Portfolyo	-	-	-
Ödev	1	10	10
Sunum / Jüri Önünde Sunum	1	20	20
Proje	-	-	-
Seminer/Çalıştay	-	-	-
Sözlü Sınav	-	-	-
Ara Sınavlar	1	20	20
Final Sınavı	1	20	20
		Toplam	150