Biyomedikal Mühendisliği

BME 315 | Ders Tanıtım Bilgileri

Dersin Adı

Molecular Biophysics

Kodu	Yarıyıl	Teori (saat/hafta)	Uygulama/Lab (saat/hafta)	Yerel Kredi	AKTS
BME 315	FALL	3	0	3	5

Ön-Koşul(lar)	GBE 100 To succeed (To get a grade of at least DD)
Dersin Dili	English
Dersin Türü	ELECTIVE_COURSE
Dersin Düzeyi	Lisans
Dersin Veriliş Şekli	Face-To-Face
Dersin Öğretim Yöntem ve Teknikleri	-
Ulusal Meslek Sınıflandırma Kodu	-
Dersin Koordinatörü	Doç. Dr. Osman Doluca
Öğretim Eleman(lar)ı	Doç. Dr. Osman Doluca
Yardımcı(ları)	-

Dersin Amacı

The aim of this course is to discuss the theories and applications of biophysics in the fields of nanomedicine and biomedical sciences. Biophysics is a promising interdisciplinary field that combines the principles and concepts of physics, biology, chemistry, biochemistry, medicine, and engineering. The objective of this course is to provide a comprehensive introduction to biological systems at the molecular and subcellular levels, with an emphasis on electrical and dynamic behavior. Additionally, the course aims to discuss fundamental theories in biomedicine and their applications through current examples.

Öğrenme Çıktıları

Bu dersi başarıyla tamamlayabilen öğrenciler;

Ad	Açıklama	PC Alt	* Katkı Düzeyi
Ad	Açıklama	PC Alt	1	2	3	4	5
LO1	Will be able to explain the terminology related to biophysics,			X
LO2	Will be able to identify biological structures and biomedical samples,				X
LO3	Will be able to describe the radiation function, the interaction of light with matter and biophysical methods,				X
LO4	Will be able to explain the applicability of biophysical principles to the biomedical field,			X
LO5	Will be able to discuss new and cutting-edge technologies in the field of biomedicine and nanobiomedicine.			X

Ders Tanımı

This course covers the binding interactions of biomolecules/biopolymers, structural-functional and dynamic properties of biomolecules (nucleic acids, proteins, lipids, etc.), enzyme mechanisms, cell membrane dynamics, membrane proteins, transport, physics of neurons, thermodynamics, bioenergetics, radiation processes, biomedical spectroscopy, infrared spectroscopy, and new approaches in nanobiomedicine and biomedical fields.

Dersin İlişkili Olduğu Sürdürülebilir Kalkınma Amaçları

Dersin Kategorisi	Temel Ders
	Uzmanlık/Alan Dersleri	X
	Destek Dersleri
	İletişim ve Yönetim Becerileri Dersleri
	Aktarılabilir Beceri Dersleri

HAFTALIK KONULAR VE İLGİLİ ÖN HAZIRLIK ÇALIŞMALARI

Hafta	Konular	Ön Hazırlık	Öğrenme Çıktısı
1	Molecular forces in biological structures: interactions, bonding, force fields, energy functions	Chapter 2, Jackson, M. B. (2006). Molecular and Cellular Biophysics. Cambridge University Press. ISBN 052162441	LO1
2	Organelles and molecular structure of cells	Chapter 1, Abeles, R. H., Frey, P. A., & Jencks, W. P. (1992). Biochemistry. Jones & Bartlett Publishers. ISBN-13 978-0867202120	LO2
3	Structural and functional properties of biomolecules - nucleic acids	Chapter 7,12,19, Abeles, R. H., Frey, P. A., & Jencks, W. P. (1992). Biochemistry. Jones & Bartlett Publishers. ISBN-13 978-0867202120	LO2
4	Structural and functional properties of biomolecules - proteins	Chapter 7,12,19, Abeles, R. H., Frey, P. A., & Jencks, W. P. (1992). Biochemistry. Jones & Bartlett Publishers. ISBN-13 978-0867202120	LO2
5	Enzyme mechanisms, Enzyme reactions and kinetics	Chapter 10, Jackson, M. B. (2006). Molecular and Cellular Biophysics. Cambridge University Press. ISBN 052162441	LO2
6	Thermodynamics, bioenergetics, ionization of biological molecules	Chapter 13, Jackson, M. B. (2006). Molecular and Cellular Biophysics. Cambridge University Press. ISBN 052162441	LO3
7	Ion permeability and membrane potential, neuron physics, nerve signals, action potential	Chapter 13, Jackson, M. B. (2006). Molecular and Cellular Biophysics. Cambridge University Press. ISBN 052162441	LO3
8	Midterm		-
9	Interaction of IR radiation with biomolecules, vibration modes; Infrared Spectroscopy in Biomedical field	Chapter 12, Atkins, P., De Paula, J., & Keeler, J. (2022). Atkins’ physical chemistry. Oxford University Press. ISBN 9780198847816	LO4
10	Radiation processes (emission, scattering, absorption) and properties of light; UV-Vis Spectroscopy, CD Spectroscopy, Fluorescence Spectroscopy, and Biomedical applications - II	Chapter 12, Atkins, P., De Paula, J., & Keeler, J. (2022). Atkins’ physical chemistry. Oxford University Press. ISBN 9780198847816	LO4
11	Radiation processes (emission, scattering, absorption) and properties of light; UV-Vis Spectroscopy, CD Spectroscopy, Fluorescence Spectroscopy, and Biomedical applications - II	Chapter 12, Atkins, P., De Paula, J., & Keeler, J. (2022). Atkins’ physical chemistry. Oxford University Press. ISBN 9780198847816	LO4
12	X-ray crystallography, diffraction; Drug/ligand interactions	Lecture notes	LO5
13	Nanobiomedicine, Drug delivery, Characterization	Lecture notes	LO5
14	Studies from recent literature on the application of biomedical and biophysical techniques to biological samples	Lecture notes	LO5
15	Review	Lecture notes	-
16	Final Exam		-

Ders Kitabı	Jackson M. B. (2006). Molecular and Cellular Biophysics. Cambridge University Press. ISBN 052162441 Atkins P. De Paula J. & Keeler J. (2022). Atkins’ physical chemistry. Oxford University Press. ISBN 9780198847816 Abeles R. H. Frey P. A. & Jencks W. P. (1992). Biochemistry. Jones & Bartlett Publishers. ISBN-13 978-0867202120
Önerilen Okumalar/Materyaller	-

DEĞERLENDİRME ÖLÇÜTLERİ

Yarıyıl Aktiviteleri	Sayı	Katkı Payı %	LO1	LO2	LO3	LO4	LO5
Küçük Sınav / Stüdyo Kritiği	1	30		X	X	X	X
Ara Sınav	1	30	X	X	X
Final Sınavı	1	40	X	X	X	X	X
Toplam	3	100

AKTS / İŞ YÜKÜ TABLOSU

Yarıyıl Aktiviteleri	Sayı	Süre (Saat)	İş Yükü
Katılım	-	-	-
Teorik Ders Saati	16	3	48
Laboratuvar / Uygulama Ders Saati	-	-	-
Sınıf Dışı Ders Çalışması	14	2	28
Arazi Çalışması	-	-	-
Küçük Sınav / Stüdyo Kritiği	1	15	15
Portfolyo	-	-	-
Ödev	-	-	-
Sunum / Jüri Önünde Sunum	-	-	-
Proje	-	-	-
Seminer/Çalıştay	-	-	-
Sözlü Sınav	-	-	-
Ara Sınavlar	1	27	27
Final Sınavı	1	32	32
		Toplam	150