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Department of Biomedical Engineering
GBE 440 | Course Introduction and Application Information
| Course Name |
Gene Therapy
|
|
Code
|
Semester
|
Theory
(hour/week) |
Application/Lab
(hour/week) |
Local Credits
|
ECTS
|
|
GBE 440
|
SPRING
|
3
|
0
|
3
|
5
|
| Prerequisites | None | |||||
| Course Language | English | |||||
| Course Type | ELECTIVE_COURSE | |||||
| Course Level | First Cycle | |||||
| Mode of Delivery | Face-To-Face | |||||
| Teaching Methods and Techniques of the Course |
Discussion Group Work Q&A Lecture / Presentation |
|||||
| National Occupational Classification Code | - | |||||
| Course Coordinator |
|
|||||
| Course Lecturer(s) |
|
|||||
| Assistant(s) | - | |||||
| Course Objectives | The aim of this course is to inform students about viral and non-viral gene transfer techniques used in gene therapy and the molecular basis of these techniques. In this course, gene therapy applications in hereditary or acquired diseases in recent years will be explained and the importance of gene therapy as a treatment option will be discussed. | |||||||||||||||||||||||||||||||||||||||||||||
| Learning Outcomes |
The students who succeeded in this course;
|
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| Course Description | This course covers the basics of gene therapy, viral and non-viral gene delivery techniques, and an explanation of how gene therapy is used as a treatment option. | |||||||||||||||||||||||||||||||||||||||||||||
| Related Sustainable Development Goals |
-
|
|||||||||||||||||||||||||||||||||||||||||||||
|
|
Core Courses |
|
| Major Area Courses |
X
|
|
| Supportive Courses |
|
|
| Media and Managment Skills Courses |
|
|
| Transferable Skill Courses |
|
WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES
| Week | Subjects | Required Materials | Learning Outcome |
| 1 | Introduction to gene therapy | A Handbook of Gene and Cell Therapy - Chapter 1 | LO1 |
| 2 | Non-viral vectors in gene therapy | A Handbook of Gene and Cell Therapy - Chapter 2 | LO2 |
| 3 | Viral vectors in gene therapy 1 | A Handbook of Gene and Cell Therapy - Chapter 3 | LO2 |
| 4 | Viral vectors in gene therapy 2 | A Handbook of Gene and Cell Therapy - Chapter 3 | LO2 |
| 5 | Barriers to gene therapy | A Handbook of Gene and Cell Therapy - Chapter 4 | LO1 |
| 6 | Stem cells and tissue regeneration-1 | A Handbook of Gene and Cell Therapy - Chapter 5 | LO1 |
| 7 | Midterm Exam | - | |
| 8 | Stem cells and tissue regeneration-2 | A Handbook of Gene and Cell Therapy - Chapter 5 | LO1 |
| 9 | Gene therapy strategies: gene augmentation | A Handbook of Gene and Cell Therapy - Chapter 6 | LO3 |
| 10 | Gene therapy strategies: gene silencing | A Handbook of Gene and Cell Therapy - Chapter 7 | LO3 |
| 11 | Gene editing | A Handbook of Gene and Cell Therapy - Chapter 8 | LO1 |
| 12 | Gene therapy applications: Preclinical studies and clinical trials | A Handbook of Gene and Cell Therapy - Chapter 9 | LO4 |
| 13 | Gene therapy in cancer | An Introduction to Molecular Medicine and Gene Therapy, Chapter 6-7 | LO4 |
| 14 | Gene Therapy for Ophthalmology and Cardiovascular Diseases | A Handbook of Gene and Cell Therapy - Chapter 9 | LO3 |
| 15 | Gene therapy in neurodegenerative diseases | - | |
| 16 | Final Exam | - |
| Course Notes/Textbooks | An Introduction to Molecular Medicine and Gene Therapy 1st Edition by Thomas F. Kresina ISBNs: 0-471-39188-3 (Hardback); 0-471-22387-5 (Electronic) |
| Suggested Readings/Materials | An Introduction to Human Molecular Genetics (2nd Edition) J.J. Pasternak 2005 |
EVALUATION SYSTEM
| Semester Activities | Number | Weighting | LO1 | LO2 | LO3 | LO4 |
| Quizzes / Studio Critiques | 1 | 10 | ||||
| Homework / Assignments | 1 | 20 | X | X | ||
| Presentation / Jury | 1 | 20 | X | X | ||
| Midterm | 1 | 20 | X | X | X | X |
| Final Exam | 1 | 30 | X | X | X | X |
| Total | 5 | 100 |
ECTS / WORKLOAD TABLE
| Semester Activities | Number | Duration (Hours) | Workload |
|---|---|---|---|
| Participation | - | - | - |
| Theoretical Course Hours | 16 | 3 | 48 |
| Laboratory / Application Hours | - | - | - |
| Study Hours Out of Class | 16 | 2 | 32 |
| Field Work | - | - | - |
| Quizzes / Studio Critiques | 1 | 5 | 5 |
| Portfolio | - | - | - |
| Homework / Assignments | 1 | 10 | 10 |
| Presentation / Jury | 1 | 15 | 15 |
| Project | - | - | - |
| Seminar / Workshop | - | - | - |
| Oral Exams | - | - | - |
| Midterms | 1 | 20 | 20 |
| Final Exam | 1 | 20 | 20 |
| Total | 150 |
COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP
| # | PC Sub | Program Competencies/Outcomes | * Contribution Level | ||||
| 1 | 2 | 3 | 4 | 5 | |||
| No program competency data found. | |||||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest
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