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Department of Biomedical Engineering
GBE 411 | Course Introduction and Application Information
| Course Name |
Design and Analysis in Bioengineering
|
|
Code
|
Semester
|
Theory
(hour/week) |
Application/Lab
(hour/week) |
Local Credits
|
ECTS
|
|
GBE 411
|
SPRING
|
2
|
2
|
3
|
6
|
| Prerequisites | None | |||||
| Course Language | English | |||||
| Course Type | Required (Core Course) | |||||
| Course Level | First Cycle | |||||
| Mode of Delivery | Face to Face | |||||
| Teaching Methods and Techniques of the Course |
Group Work Problem Solving Lecture / Presentation Application: Interactive Learning |
|||||
| National Occupational Classification Code | - | |||||
| Course Coordinator |
|
|||||
| Course Lecturer(s) |
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| Assistant(s) | - | |||||
| Course Objectives | The aim of this course is to convey theoretical and practical concepts related to the interpretation and application of bioengineering principles and knowledge, acquired throughout the educational process, within the context of process design. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning Outcomes |
The students who succeeded in this course;
|
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| Course Description | This course covers the identification of design principles and methods encountered in bioengineering, tracking development processes, reviewing relevant resources, selecting and evaluating potential raw materials and productions, determining and utilizing capacity, creating process design flow diagrams, mass and energy balances for the selected system, equipment and bioreactor design, designing the separation and purification process, and conducting feasibility studies. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Related Sustainable Development Goals |
-
|
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|
|
Core Courses |
X
|
| Major Area Courses |
|
|
| Supportive Courses |
|
|
| Media and Managment Skills Courses |
|
|
| Transferable Skill Courses |
|
WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES
| Week | Subjects | Required Materials | Learning Outcome |
| 1 | Definition of the bioprocess and development processes | Interactive study and articles Chapter 1, Bioprocess Engineering Principles (2nd Edition) | LO1 |
| 2 | Market research, determination of capacity and raw materials | Interactive study and articles Chapter 3, Bioprocess Engineering Principles (2nd Edition) | LO2 |
| 3 | Creation of flow diagrams | Interactive study and articles Chapters 4 and 5, Bioprocess Engineering Principles (2nd Edition) | LO2 |
| 4 | Mass and energy balances | Interactive study and articles Chapters 4 and 5, Bioprocess Engineering Principles (2nd Edition) | LO3 |
| 5 | Identification of basic equipment | Interactive study and articles Chapter 11, Bioprocess Engineering Principles (2nd Edition) | LO3 |
| 6 | Pretreatments | Interactive study and articles Chapter 11, Bioprocess Engineering Principles (2nd Edition) | LO3 |
| 7 | Research on reaction and microbial kinetics | Interactive study and articles Chapter 2, Bioprocess Engineering Principles (2nd Edition) | LO4 |
| 8 | Review and Midterm | - | |
| 9 | Explanation of bioreactor types and selection specific to the process, bioreactor design | Interactive study and articles Chapter 14, Bioprocess Engineering Principles (2nd Edition) | LO4 |
| 10 | Bioreactor design | Interactive study and articles Chapter 14, Bioprocess Engineering Principles (2nd Edition) | LO4 |
| 11 | Equipment selection , determination of piping system, pump, valve, connectors | Interactive study and articles Chapter 11, Bioprocess Engineering Principles (2nd Edition) | LO4 |
| 12 | Evaluation of separation and purification processes | Interactive study Singh & Herzer (2018), Adv Biochem Eng Biotechnol, 165:115–178 | LO5 |
| 13 | Design and analysis of the separation and purification process Feasibility analysis | Interactive study Singh & Herzer (2018), Adv Biochem Eng Biotechnol, 165:115–178; Pollock et al. (2017), Biotechnol Prog, 33(4): 854–866 | LO6 |
| 14 | Project presentations | - | |
| 15 | Project presentations | - | |
| 16 | General semester review | - |
| Course Notes/Textbooks | Tietz Textbook of Clinical Chemistry and Molecular Diagnostics (6th edition). Rifai- Horvath- Wittwer. Elsevier 2018 ISBN: 978-0-323-35921-4 Computational Drug Discovery and Design. Springer Protocols- Humana Press- 2018. Gore and Jagtap. ISBN 978-1-4939-7755-0 Bioprocess Engineering Principles (2nd Edition)- Doran P- Academic Press- 2012. ISBN: 978-0122208515 |
| Suggested Readings/Materials | Experimental design methods for bioengineering applications. Gundogdu et al. Crit Rev Biotechnol. 2016;36(2):368-88. Model-assisted design of experiments as a concept for knowledge-based bioprocess development. Moller et al. Bioprocess Biosyst Eng. 2019 May;42(5):867-882. Downstream Processing Technologies/Capturing and Final Purification : Opportunities for Innovation Change and Improvement. A Review of Downstream Processing Developments in Protein Purification. Singh and Herzer. Adv Biochem Eng Biotechnol. 2018;165:115-178. Integrated continuous bioprocessing: Economic operational and environmental feasibility for clinical and commercial antibody manufacture. Pollock et al. Biotechnol Prog. 2017 ; 33(4): 854–866. Heller et al. Annu Rev Anal Chem (Palo Alto Calif). 2018; 12;11(1):79-100. |
EVALUATION SYSTEM
| Semester Activities | Number | Weighting | LO1 | LO2 | LO3 | LO4 | LO5 | LO6 |
| Homework / Assignments | 1 | 20 | X | X | ||||
| Presentation / Jury | 1 | 20 | X | X | X | |||
| Project | 1 | 30 | X | X | X | X | ||
| Midterm | 1 | 30 | X | X | X | |||
| Total | 4 | 100 |
ECTS / WORKLOAD TABLE
| Semester Activities | Number | Duration (Hours) | Workload |
|---|---|---|---|
| Participation | - | - | - |
| Theoretical Course Hours | 16 | 2 | 32 |
| Laboratory / Application Hours | 16 | 2 | 32 |
| Study Hours Out of Class | 14 | 2 | 28 |
| Field Work | - | - | - |
| Quizzes / Studio Critiques | - | - | - |
| Portfolio | - | - | - |
| Homework / Assignments | 5 | 3 | 15 |
| Presentation / Jury | 1 | 5 | 5 |
| Project | 1 | 20 | 20 |
| Seminar / Workshop | - | - | - |
| Oral Exams | - | - | - |
| Midterms | 1 | 18 | 18 |
| Final Exam | - | - | - |
| Total | 150 |
COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP
| # | PC Sub | Program Competencies/Outcomes | * Contribution Level | ||||
| 1 | 2 | 3 | 4 | 5 | |||
| No program competency data found. | |||||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest
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