Department of Biomedical Engineering

GBE 370 | Course Introduction and Application Information

Course Name

Molecular Immunology

Code	Semester	Theory (hour/week)	Application/Lab (hour/week)	Local Credits	ECTS
GBE 370	SPRING	3	0	3	6

Prerequisites	None
Course Language	English
Course Type	ELECTIVE_COURSE
Course Level	First Cycle
Mode of Delivery	Face to Face
Teaching Methods and Techniques of the Course	Discussion Group Work Q&A Lecture / Presentation
National Occupational Classification Code	-
Course Coordinator	Dr. Öğr. Üyesi Yağmur Kiraz Durmaz
Course Lecturer(s)	Dr. Öğr. Üyesi Yağmur Kiraz Durmaz
Assistant(s)	-

Course Objectives

The objective of this course is to teach the cells and tissues that comprise the immune system and the differences between innate and adaptive immunity. Also, it aims to explain the selection, tolerance, memory mechanisms of immune system and relationships between immunity and diseases. This course, according to genetics and bioengineering based studies, will provide important background knowledge especially on the topics of immune system mechanisms and their effect on disease durations.

Learning Outcomes

The students who succeeded in this course;

Name	Description	PC Sub	* Contribution Level
Name	Description	PC Sub	1	2	3	4	5
LO1	Classify cells, receptors and molecules that are part of the immune system,	1.5		X
LO2	Discuss the key features of innate and adaptive immunity,	1.5		X
LO3	Explain the concept of B cell development and function, antibody formation, structure and effector function together with T cell development and function, cytokines and their essential functions, and effects on the immune system	1.5		X
LO4	Describe the basic concepts of antigen presentation and structure and function of antigen-presenting molecules,	1.5		X
LO5	Explain tumor immunity, autoimmunity and immunity to viruses and how immunity relates to diseases, design a research project on immunotherapy;	5.1		X
LO6	Discuss immunology-related research articles.	5.1		X

Course Description

This course will include discussion of the properties of innate and adaptive immunity, the cells of the immune system. Additionally, students will learn about antibody structure and function, antigen recognition, lymphocyte activation, and immunity to microbes. Immunity that relates to diseases will also be covered including autoimmunity, transplantation, immunity to viruses and tumor immunology.

Related Sustainable Development Goals

Course Category	Core Courses
	Major Area Courses	X
	Supportive Courses
	Media and Managment Skills Courses
	Transferable Skill Courses

WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES

Week	Subjects	Required Materials	Learning Outcome
1	Introduction to Immune System, Cells of the Immune System & Lymphoid Organs	Janeway’s Immunobiology 9th Edition, Part I	d64449ba
2	Innate Immunity	Janeway’s Immunobiology 9th Edition, Part I	a9bde996
3	Adaptive Immunity	Janeway’s Immunobiology 9th Edition, Part IV	a9bde996
4	B-Cells and Antibodies / Antibody Classes & Functions	Janeway’s Immunobiology 9th Edition, Part II	757644d1
5	Antigen Presentation / MHC Classes	Janeway’s Immunobiology 9th Edition, Part II	491dabd6
6	T-Cell Activation and Signaling,Receptors, Response	Janeway’s Immunobiology 9th Edition, Part IV	491dabd6
7	Research Paper Presentations		-
8	Midterm		-
9		Janeway’s Immunobiology 9th Edition, Part V	d7768f1a
10	Tumor Immunology / Immunotherapy	Janeway’s Immunobiology 9th Edition, Part V	d7768f1a
11	Transplantation	Janeway’s Immunobiology 9th Edition, Part V	dea00170
12	Immunity to Viruses / Vaccinology	Janeway’s Immunobiology 9th Edition, Part V	dea00170
13	Research Paper Presentations		-
14	Research Paper Presentations		-
15	Review		-
16	Final Exam		-

Course Notes/Textbooks	Janeway’s Immunobiology 9th Edition- Kenneth Murphy & Casey Weaver 2016 Garland Science ISBN-13: 9781315533247 ISBN: 1315533243
Suggested Readings/Materials	Kuby Immunology by Kindt- Goldsby and Osborne 2007. W.H. Freeman and Company- New York

EVALUATION SYSTEM

Semester Activities	Number	Weighting	LO1	LO2	LO3	LO4	LO5	LO6
Quizzes / Studio Critiques	1	5	X	X
Homework / Assignments	1	10			X	X
Presentation / Jury	1	20					X	X
Project	1	15					X	X
Midterm	1	20	X	X	X
Final Exam	1	30	X	X	X	X	X	X
Total	6	100

ECTS / WORKLOAD TABLE

Semester Activities	Number	Duration (Hours)	Workload
Participation	-	-	-
Theoretical Course Hours	16	3	48
Laboratory / Application Hours	-	-	-
Study Hours Out of Class	14	2	28
Field Work	-	-	-
Quizzes / Studio Critiques	1	10	10
Portfolio	-	-	-
Homework / Assignments	1	10	10
Presentation / Jury	1	20	20
Project	1	20	20
Seminar / Workshop	-	-	-
Oral Exams	-	-	-
Midterms	1	20	20
Final Exam	1	24	24
		Total	180

COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP

#	PC Sub	Program Competencies/Outcomes	* Contribution Level
#	PC Sub	Program Competencies/Outcomes	1	2	3	4	5
1	Engineering Knowledge: Knowledge of mathematics, science, basic engineering, computation, and related engineering discipline-specific topics; the ability to apply this knowledge to solve complex engineering problems.
	1	Mathematics
	2	Science
	3	Basic Engineering
	4	Computation
	5	Related engineering discipline-specific topics		LO1 LO2 LO3 LO4
	6	The ability to apply this knowledge to solve complex engineering problems
2	Problem Analysis: Ability to identify, formulate and analyze complex engineering problems using basic knowledge of science, mathematics and engineering, and considering the UN Sustainable Development Goals relevant to the problem being addressed.
3	Engineering Design: The ability to devise creative solutions to complex engineering problems; the ability to design complex systems, processes, devices or products to meet current and future needs, considering realistic constraints and conditions.
	1	Ability to design creative solutions to complex engineering problems
	2	Ability to design complex systems, processes, devices or products to meet current and future needs, considering realistic constraints and conditions
4	Use of Techniques and Tools: Ability to select and use appropriate techniques, resources, and modern engineering and computing tools, including estimation and modeling, for the analysis and solution of complex engineering problems, while recognizing their limitations.
5	Research and Investigation: Ability to use research methods to investigate complex engineering problems, including literature research, designing and conducting experiments, collecting data, and analyzing and interpreting results.
	1	Literature research for the study of complex engineering problems		LO5 LO6
	2	Designing experiments
	3	Ability to use research methods, including conducting experiments, collecting data. analyzing and interpreting results
6	Global Impact of Engineering Practices: Knowledge of the impacts of engineering practices on society, health and safety, economy, sustainability, and the environment, within the context of the UN Sustainable Development Goals; awareness of the legal implications of engineering solutions.
	1	Knowledge of the impacts of engineering practices on society, health and safety, economy, sustainability, and the environment, within the context of the UN Sustainable Development Goals
	2	Awareness of the legal implications of engineering solutions
7	Ethical Behavior: Acting in accordance with the principles of the engineering profession, knowledge about ethical responsibility; awareness of being impartial, without discrimination, and being inclusive of diversity.
	1	Acting in accordance with the principles of the engineering profession, knowledge about ethical responsibility ethical responsibility
	2	Awareness of being impartial and inclusive of diversity, without discriminating on any subject
8	Individual and Teamwork: Ability to work effectively, individually and as a team member or leader on interdisciplinary and multidisciplinary teams (face-to-face, remote or hybrid).
	1	Ability to work individually and within the discipline
	2	Ability to work effectively as a team member or leader in multidisciplinary teams (face-to-face, remote or hybrid)
9	Verbal and Written Communication: Taking into account the various differences of the target audience (such as education, language, profession) on technical issues.
	1	Ability to communicate verbally
	2	Ability to communicate effectively in writing
10	Project Management: Knowledge of business practices such as project management and economic feasibility analysis; awareness of entrepreneurship and innovation.
	1	Knowledge of business practices such as project management and economic feasibility analysis
	2	Awareness of entrepreneurship and innovation
11	Lifelong Learning: Lifelong learning skills that include being able to learn independently and continuously, adapting to new and developing technologies, and thinking questioningly about technological changes.