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Department of Biomedical Engineering
GBE 360 | Course Introduction and Application Information
| Course Name |
Cell Signaling
|
|
Code
|
Semester
|
Theory
(hour/week) |
Application/Lab
(hour/week) |
Local Credits
|
ECTS
|
|
GBE 360
|
SPRING
|
3
|
0
|
3
|
5
|
| Prerequisites | None | |||||
| Course Language | English | |||||
| Course Type | ELECTIVE_COURSE | |||||
| Course Level | First Cycle | |||||
| Mode of Delivery | Face-To-Face | |||||
| Teaching Methods and Techniques of the Course |
Discussion Group Work Q&A Lecture / Presentation |
|||||
| National Occupational Classification Code | - | |||||
| Course Coordinator |
|
|||||
| Course Lecturer(s) |
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| Assistant(s) | - | |||||
| Course Objectives | This course aims to provide students with information about the mechanisms of intracellular signaling and to address the importance of signaling in physiology and diseases. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning Outcomes |
The students who succeeded in this course;
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||
| Course Description | Fundamental aspects of cell signaling. Characterization of intracellular signaling structures: signaling molecules, receptors, second messengers, effectors, signaling complexes. Classification and properties of membrane receptors. Intracellular/nuclear receptors. Major signaling pathways. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Related Sustainable Development Goals |
-
|
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|
|
Core Courses |
|
| Major Area Courses |
X
|
|
| Supportive Courses |
|
|
| Media and Managment Skills Courses |
|
|
| Transferable Skill Courses |
|
WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES
| Week | Subjects | Required Materials | Learning Outcome |
| 1 | Signal Transduction Mechanisms: Signals and Sensors | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 1-1,2 | 10df02e4 |
| 2 | Signal Transduction Mechanisms: Secondary Messengers | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 1-3 | 10df02e4 |
| 3 | Signaling Pathways: G-Protein Coupled Receptors | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 2 | 4a9d0b68 |
| 4 | Signaling Pathways: Receptor and Nonreceptor Tyrosine Kinases | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 2 | 4a9d0b68 |
| 5 | Signaling Pathways: Serine/Threonine Kinase Coupled Receptors | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 2 | 4a9d0b68 |
| 6 | Signaling Pathways: Mitogen-Activated Protein Kinases | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 2 | 4a9d0b68 |
| 7 | Signaling Pathways: Phosphatidylinositol-Mediated Signaling | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 2 | 4a9d0b68 |
| 8 | Midterm Exam | - | |
| 9 | Growth Factor Signals | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3 | 34183f2e |
| 10 | Cell Death Signals | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3 | 34183f2e |
| 11 | DNA Damage Response | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3 | 34183f2e |
| 12 | Heat Shock and ER Stress Response | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3 | 34183f2e |
| 13 | Metabolism and Signaling | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3 | eaa26005 |
| 14 | Signal Transduction in Health and Disease | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3 | d04b24fc |
| 15 | Semester Review | - | |
| 16 | Final Exam | - |
| Course Notes/Textbooks | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Lewis Cantley & Tony Thunter & Richard Sever and Jeremy Thorner. |
| Suggested Readings/Materials |
Cellular Signaling Processing. 2008. Garland Science. Friedrich Marks & Ursula Klingmuller and Karin Muller-Decker Biochemistry of Signal Transduction and Regulation. 2014. Wiley-VCH. Gerhard Krauss Signal Transduction. 2015. Academic Press. Bastien D. Gomperts & Ijsbrand M. Kramer and Peter E. R. Tatham. |
EVALUATION SYSTEM
| Semester Activities | Number | Weighting | LO1 | LO2 | LO3 | LO4 | LO5 |
| Homework / Assignments | 1 | 20 | X | X | X | ||
| Presentation / Jury | 1 | 20 | X | X | X | ||
| Midterm | 1 | 30 | X | X | X | ||
| Final Exam | 1 | 30 | X | X | X | X | X |
| Total | 4 | 100 |
ECTS / WORKLOAD TABLE
| Semester Activities | Number | Duration (Hours) | Workload |
|---|---|---|---|
| Participation | - | - | - |
| Theoretical Course Hours | 16 | 3 | 48 |
| Laboratory / Application Hours | - | - | - |
| Study Hours Out of Class | 14 | 2 | 28 |
| Field Work | - | - | - |
| Quizzes / Studio Critiques | - | - | - |
| Portfolio | - | - | - |
| Homework / Assignments | 1 | 12 | 12 |
| Presentation / Jury | 1 | 20 | 20 |
| Project | - | - | - |
| Seminar / Workshop | - | - | - |
| Oral Exams | - | - | - |
| Midterms | 1 | 17 | 17 |
| Final Exam | 1 | 25 | 25 |
| Total | 150 |
COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP
| # | PC Sub | Program Competencies/Outcomes | * Contribution Level | ||||
| 1 | 2 | 3 | 4 | 5 | |||
| No program competency data found. | |||||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest
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