Department of Biomedical Engineering

GBE 360 | Course Introduction and Application Information

Course Name

Cell Signaling

Code	Semester	Theory (hour/week)	Application/Lab (hour/week)	Local Credits	ECTS
GBE 360	SPRING	3	0	3	5

Prerequisites	None
Course Language	English
Course Type	ELECTIVE_COURSE
Course Level	First Cycle
Mode of Delivery	Face-To-Face
Teaching Methods and Techniques of the Course	Discussion Group Work Q&A Lecture / Presentation
National Occupational Classification Code	-
Course Coordinator	Dr. Öğr. Üyesi Yağmur Kiraz Durmaz
Course Lecturer(s)	Dr. Öğr. Üyesi Yağmur Kiraz Durmaz
Assistant(s)	-

Course Objectives

This course aims to provide students with information about the mechanisms of intracellular signaling and to address the importance of signaling in physiology and diseases.

Learning Outcomes

The students who succeeded in this course;

Name	Description	PC Sub	* Contribution Level
Name	Description	PC Sub	1	2	3	4	5
LO1	Describe signal transduction and the biological properties of this system	1.5		X
LO2	Understand and compare the diversity of signaling mechanisms: receptors, ligands, second messengers, adapters, post-translational modifications	1.5		X
LO3	Explain the relationship between signal transduction and development, diseases and health.	1.5		X
LO4	Critically discuss the literature on signal transduction	5.1		X
LO5	Discuss existing paradigms of signal transduction, ask new questions, and hypothesize	5.1		X

Course Description

Fundamental aspects of cell signaling. Characterization of intracellular signaling structures: signaling molecules, receptors, second messengers, effectors, signaling complexes. Classification and properties of membrane receptors. Intracellular/nuclear receptors. Major signaling pathways.

Related Sustainable Development Goals

Course Category	Core Courses
	Major Area Courses	X
	Supportive Courses
	Media and Managment Skills Courses
	Transferable Skill Courses

WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES

Week	Subjects	Required Materials	Learning Outcome
1	Signal Transduction Mechanisms: Signals and Sensors	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 1-1,2	10df02e4
2	Signal Transduction Mechanisms: Secondary Messengers	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 1-3	10df02e4
3	Signaling Pathways: G-Protein Coupled Receptors	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 2	4a9d0b68
4	Signaling Pathways: Receptor and Nonreceptor Tyrosine Kinases	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 2	4a9d0b68
5	Signaling Pathways: Serine/Threonine Kinase Coupled Receptors	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 2	4a9d0b68
6	Signaling Pathways: Mitogen-Activated Protein Kinases	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 2	4a9d0b68
7	Signaling Pathways: Phosphatidylinositol-Mediated Signaling	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 2	4a9d0b68
8	Midterm Exam		-
9	Growth Factor Signals	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3	34183f2e
10	Cell Death Signals	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3	34183f2e
11	DNA Damage Response	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3	34183f2e
12	Heat Shock and ER Stress Response	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3	34183f2e
13	Metabolism and Signaling	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3	eaa26005
14	Signal Transduction in Health and Disease	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3	d04b24fc
15	Semester Review		-
16	Final Exam		-

Course Notes/Textbooks	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Lewis Cantley & Tony Thunter & Richard Sever and Jeremy Thorner.
Suggested Readings/Materials	Cellular Signaling Processing. 2008. Garland Science. Friedrich Marks & Ursula Klingmuller and Karin Muller-Decker Biochemistry of Signal Transduction and Regulation. 2014. Wiley-VCH. Gerhard Krauss Signal Transduction. 2015. Academic Press. Bastien D. Gomperts & Ijsbrand M. Kramer and Peter E. R. Tatham.

EVALUATION SYSTEM

Semester Activities	Number	Weighting	LO1	LO2	LO3	LO4	LO5
Homework / Assignments	1	20	X	X	X
Presentation / Jury	1	20			X	X	X
Midterm	1	30	X	X	X
Final Exam	1	30	X	X	X	X	X
Total	4	100

ECTS / WORKLOAD TABLE

Semester Activities	Number	Duration (Hours)	Workload
Participation	-	-	-
Theoretical Course Hours	16	3	48
Laboratory / Application Hours	-	-	-
Study Hours Out of Class	14	2	28
Field Work	-	-	-
Quizzes / Studio Critiques	-	-	-
Portfolio	-	-	-
Homework / Assignments	1	12	12
Presentation / Jury	1	20	20
Project	-	-	-
Seminar / Workshop	-	-	-
Oral Exams	-	-	-
Midterms	1	17	17
Final Exam	1	25	25
		Total	150

COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP

#	PC Sub	Program Competencies/Outcomes	* Contribution Level
#	PC Sub	Program Competencies/Outcomes	1	2	3	4	5
1	Engineering Knowledge: Knowledge of mathematics, science, basic engineering, computation, and related engineering discipline-specific topics; the ability to apply this knowledge to solve complex engineering problems.
	1	Mathematics
	2	Science
	3	Basic Engineering
	4	Computation
	5	Related engineering discipline-specific topics		LO1 LO2 LO3
	6	The ability to apply this knowledge to solve complex engineering problems
2	Problem Analysis: Ability to identify, formulate and analyze complex engineering problems using basic knowledge of science, mathematics and engineering, and considering the UN Sustainable Development Goals relevant to the problem being addressed.
3	Engineering Design: The ability to devise creative solutions to complex engineering problems; the ability to design complex systems, processes, devices or products to meet current and future needs, considering realistic constraints and conditions.
	1	Ability to design creative solutions to complex engineering problems
	2	Ability to design complex systems, processes, devices or products to meet current and future needs, considering realistic constraints and conditions
4	Use of Techniques and Tools: Ability to select and use appropriate techniques, resources, and modern engineering and computing tools, including estimation and modeling, for the analysis and solution of complex engineering problems, while recognizing their limitations.
5	Research and Investigation: Ability to use research methods to investigate complex engineering problems, including literature research, designing and conducting experiments, collecting data, and analyzing and interpreting results.
	1	Literature research for the study of complex engineering problems		LO4 LO5
	2	Designing experiments
	3	Ability to use research methods, including conducting experiments, collecting data. analyzing and interpreting results
6	Global Impact of Engineering Practices: Knowledge of the impacts of engineering practices on society, health and safety, economy, sustainability, and the environment, within the context of the UN Sustainable Development Goals; awareness of the legal implications of engineering solutions.
	1	Knowledge of the impacts of engineering practices on society, health and safety, economy, sustainability, and the environment, within the context of the UN Sustainable Development Goals
	2	Awareness of the legal implications of engineering solutions
7	Ethical Behavior: Acting in accordance with the principles of the engineering profession, knowledge about ethical responsibility; awareness of being impartial, without discrimination, and being inclusive of diversity.
	1	Acting in accordance with the principles of the engineering profession, knowledge about ethical responsibility ethical responsibility
	2	Awareness of being impartial and inclusive of diversity, without discriminating on any subject
8	Individual and Teamwork: Ability to work effectively, individually and as a team member or leader on interdisciplinary and multidisciplinary teams (face-to-face, remote or hybrid).
	1	Ability to work individually and within the discipline
	2	Ability to work effectively as a team member or leader in multidisciplinary teams (face-to-face, remote or hybrid)
9	Verbal and Written Communication: Taking into account the various differences of the target audience (such as education, language, profession) on technical issues.
	1	Ability to communicate verbally
	2	Ability to communicate effectively in writing
10	Project Management: Knowledge of business practices such as project management and economic feasibility analysis; awareness of entrepreneurship and innovation.
	1	Knowledge of business practices such as project management and economic feasibility analysis
	2	Awareness of entrepreneurship and innovation
11	Lifelong Learning: Lifelong learning skills that include being able to learn independently and continuously, adapting to new and developing technologies, and thinking questioningly about technological changes.