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Department of Biomedical Engineering
GBE 355 | Course Introduction and Application Information
| Course Name |
Microbial Biofilms
|
|
Code
|
Semester
|
Theory
(hour/week) |
Application/Lab
(hour/week) |
Local Credits
|
ECTS
|
|
GBE 355
|
SPRING
|
3
|
0
|
3
|
5
|
| Prerequisites | None | |||||
| Course Language | English | |||||
| Course Type | ELECTIVE_COURSE | |||||
| Course Level | First Cycle | |||||
| Mode of Delivery | Face to Face | |||||
| Teaching Methods and Techniques of the Course | Lecture/Presentation & Discussion & Grup Study & Q&A | |||||
| National Occupational Classification Code | - | |||||
| Course Coordinator |
|
|||||
| Course Lecturer(s) |
|
|||||
| Assistant(s) | - | |||||
| Course Objectives | The aim of this course is to explain the formation and dispersion processes of microbial biofilms and the environmental signals and signaling networks regulating these processes, to provide information about biofilm infections, biofouling, and the strategies to combat biofilms. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning Outcomes |
The students who succeeded in this course;
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||
| Course Description | This course covers the formation of microbial biofilms, the structure and functions of the extracellular polymeric substance synthesized in biofilm formation, environmental signals and intracellular and intercellular signaling networks regulating the biofilm formation and dispersion processes, and biofouling on surfaces, chronic infections and implant-associated infections caused by biofilms. In addition, this course also provides information on the current strategies developed to combat biofilms. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Related Sustainable Development Goals |
-
|
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|
|
Core Courses |
|
| Major Area Courses |
X
|
|
| Supportive Courses |
|
|
| Media and Managment Skills Courses |
|
|
| Transferable Skill Courses |
|
WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES
| Week | Subjects | Required Materials | Learning Outcome |
| 1 | Introduction to biofilms | Staffan Kjelleberg, Michael Givskov. The Biofilm Mode of Life: Mechanisms and Adaptations, 1st Edition. Horizon Bioscience, 2007. Chapter 1 | LO1 |
| 2 | Mechanisms of bacterial adhesion, biofilm formation, biofilm life cycle | Staffan Kjelleberg, Michael Givskov. The Biofilm Mode of Life: Mechanisms and Adaptations, 1st Edition. Horizon Bioscience, 2007. Chapter 2 and Chapter 3 | LO1 |
| 3 | Functions and components of extracellular polymeric biofilm matrix (EPS) | Staffan Kjelleberg, Michael Givskov. The Biofilm Mode of Life: Mechanisms and Adaptations, 1st Edition. Horizon Bioscience, 2007. Chapter 4 | LO1 |
| 4 | Regulatory signaling networks of biofilm formation and dispersion, and cyclic diguanylate monophosphate (c-di GMP) | Staffan Kjelleberg, Michael Givskov. The Biofilm Mode of Life: Mechanisms and Adaptations, 1st Edition. Horizon Bioscience, 2007. Chapter 5 | LO2 |
| 5 | Regulatory signaling networks of biofilm formation and dispersion, and quorum sensing | Staffan Kjelleberg, Michael Givskov. The Biofilm Mode of Life: Mechanisms and Adaptations, 1st Edition. Horizon Bioscience, 2007. Chapter 6 Rina Rani Ray, Moupriya Nag, Dibyajit Lahiri. Biofilm-Mediated Diseases: Causes and Controls, 1st Edition. Springer Nature, 2021. Chapter 2 | LO2 |
| 6 | Biofilm dispersion | Staffan Kjelleberg, Michael Givskov. The Biofilm Mode of Life: Mechanisms and Adaptations, 1st Edition. Horizon Bioscience, 2007. Chapter 9 | LO3 |
| 7 | Biofilms and biofouling | Rina Rani Ray, Moupriya Nag, Dibyajit Lahiri. Biofilm-Mediated Diseases: Causes and Controls, 1st Edition. Springer Nature, 2021. Chapter 4 | LO3 |
| 8 | Midterm Exam | - | |
| 9 | Biofilms and chronic infections | Rina Rani Ray, Moupriya Nag, Dibyajit Lahiri. Biofilm-Mediated Diseases: Causes and Controls, 1st Edition. Springer Nature, 2021. Chapter 4 and Chapter 5 | LO4 |
| 10 | Biofilms and implant-associated infections | Rina Rani Ray, Moupriya Nag, Dibyajit Lahiri. Biofilm-Mediated Diseases: Causes and Controls, 1st Edition. Springer Nature, 2021. Chapter 7 | LO4 |
| 11 | Biofilms and antimicrobial resistance | Rina Rani Ray, Moupriya Nag, Dibyajit Lahiri. Biofilm-Mediated Diseases: Causes and Controls, 1st Edition. Springer Nature, 2021. Chapter 8 | LO4 |
| 12 | Control and inhibition of biofilm formation, strategies that trigger biofilm dispersion | Rina Rani Ray, Moupriya Nag, Dibyajit Lahiri. Biofilm-Mediated Diseases: Causes and Controls, 1st Edition. Springer Nature, 2021. Chapter 9 and Chapter 10 | LO5 |
| 13 | Novel treatment strategies for biofilm infections | Rina Rani Ray, Moupriya Nag, Dibyajit Lahiri. Biofilm-Mediated Diseases: Causes and Controls, 1st Edition. Springer Nature, 2021. Chapter 10 | LO5 |
| 14 | Student Presentations | - | |
| 15 | Semester Review | - | |
| 16 | Final Exam | - |
| Course Notes/Textbooks | - |
| Suggested Readings/Materials | - |
EVALUATION SYSTEM
| Semester Activities | Number | Weighting | LO1 | LO2 | LO3 | LO4 | LO5 |
| Homework / Assignments | 1 | 15 | X | X | X | ||
| Presentation / Jury | 1 | 20 | X | ||||
| Midterm | 1 | 25 | X | X | X | ||
| Final Exam | 1 | 40 | X | X | X | X | |
| Total | 4 | 100 |
ECTS / WORKLOAD TABLE
| Semester Activities | Number | Duration (Hours) | Workload |
|---|---|---|---|
| Participation | - | - | - |
| Theoretical Course Hours | 16 | 3 | 48 |
| Laboratory / Application Hours | - | - | - |
| Study Hours Out of Class | 14 | 2 | 28 |
| Field Work | - | - | - |
| Quizzes / Studio Critiques | - | - | - |
| Portfolio | - | - | - |
| Homework / Assignments | 1 | 15 | 15 |
| Presentation / Jury | 1 | 18 | 18 |
| Project | - | - | - |
| Seminar / Workshop | - | - | - |
| Oral Exams | - | - | - |
| Midterms | 1 | 18 | 18 |
| Final Exam | 1 | 23 | 23 |
| Total | 150 |
COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP
| # | PC Sub | Program Competencies/Outcomes | * Contribution Level | ||||
| 1 | 2 | 3 | 4 | 5 | |||
| No program competency data found. | |||||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest
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