Department of Biomedical Engineering

GBE 208 | Course Introduction and Application Information

Course Name

General and Molecular Biology 2

Code	Semester	Theory (hour/week)	Application/Lab (hour/week)	Local Credits	ECTS
GBE 208	SPRING	2	2	3	5

Prerequisites	None
Course Language	English
Course Type	Required (Core Course)
Course Level	First Cycle
Mode of Delivery	Face-To-Face
Teaching Methods and Techniques of the Course	Lecture / Presentation Q&A Discussion
National Occupational Classification Code	-
Course Coordinator	Prof. Dr. Zeynep Fırtına Karagonlar
Course Lecturer(s)	Prof. Dr. Zeynep Fırtına Karagonlar
Assistant(s)	Araş. Gör. Mehmet Serdar Çakan

Course Objectives

In this course, the internal organization of eukaryotic cells, organelle and membrane functions, cell-cell adhesion, cytoskeleton and extracellular matrix structure and function will be examined. The course will cover important cellular processes such as membrane structure and composition, transport and vesicular transport, cytoskeleton and cellular movement, formation of tissues from cells and regulation of the cell cycle, apoptosis, regeneration, repair and cancer cell biology.

Learning Outcomes

The students who succeeded in this course;

Name	Description	PC Sub	* Contribution Level
Name	Description	PC Sub	1	2	3	4	5
LO1	Describe cell structure and cytoskeleton, cell-cell and cell-extracellular matrix adhesion, and their relationships with cellular functions	1.2				X
LO2	Explain how cellular transport and secretion occur	1.4				X
LO3	Explain how cells grow, divide and die and how these important processes are regulated	2			X
LO4	Discuss how disruptions in cellular processes lead to cancer and other diseases.	3.1			X
LO5	Describe the different types of stem cells and their roles in tissue regeneration and repair processes	3.1			X
LO6	Be able to design disease models using engineering techniques and within realistic constraints	3.2			X

Course Description

This course will cover the internal organization of the eukaryotic cell, organelle and membrane function, cell-cell signaling, cellular transport and secretion, extracellular matrix, cell division and apoptosis. Additionally, stem cells, tissue regeneration and repair, and iPSC technology will be discussed.

Related Sustainable Development Goals

Course Category	Core Courses	X
	Major Area Courses
	Supportive Courses
	Media and Managment Skills Courses
	Transferable Skill Courses

WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES

Week	Subjects	Required Materials	Learning Outcome
1	Cell Structure and Organelles	Molecular Biology of the Cell, 6th edition, Garland Science. ISBN	e50f6cf7
2	Cell Membrane and Transport	Molecular Biology of the Cell, Chapters 10 & 11	13260beb
3	Cellular secretion and Vesicular Transport	Molecular Biology of the Cell, Chapters 12 & 13	13260beb
4	Protein Secretory Pathways	Molecular Biology of the Cell, Chapter 13	13260beb
5	Extracellular Matrix	Molecular Biology of the Cell, Chapter 19	13260beb
6	Midterm Exam		-
7	Cell-cell and Cell-ECM Adhesion	Molecular Biology of the Cell, Chapter 19	e50f6cf7
8	Cell-cell Interaction	Molecular Biology of the Cell, Chapter 15	e50f6cf7
9	Cell growth and division	Molecular Biology of the Cell, Chapter 17	a01ed789
10	Cell Death	Molecular Biology of the Cell, Chapter 18	a01ed789
11	Tissue repair and regeneration	Molecular Biology of the Cell, Chapter 22	0d37bd34
12	Tissue repair and regeneration	Molecular Biology of the Cell, Chapter 22	7eb67e53
13	Stem Cells	Molecular Biology of the Cell, Chapter 22	0d37bd34
14	Cancer	Molecular Biology of the Cell, Chapter 22	3f870643
15	Presentations		7eb67e53
16	Final Exam		-

Course Notes/Textbooks	Alberts et.al. Molecular Biology of the Cell. 6th edition. Garland Science. ISBN 9780815344643
Suggested Readings/Materials	-

EVALUATION SYSTEM

Semester Activities	Number	Weighting	LO1	LO2	LO3	LO4	LO5	LO6
Quizzes / Studio Critiques	1	10	X	X	X
Presentation / Jury	1	10					X	X
Project	1	10					X	X
Midterm	1	30	X	X	X	X
Final Exam	1	40			X	X	X
Total	5	100

ECTS / WORKLOAD TABLE

Semester Activities	Number	Duration (Hours)	Workload
Participation	-	-	-
Theoretical Course Hours	16	2	32
Laboratory / Application Hours	16	2	32
Study Hours Out of Class	-	-	-
Field Work	-	-	-
Quizzes / Studio Critiques	1	15	15
Portfolio	-	-	-
Homework / Assignments	-	-	-
Presentation / Jury	1	14	14
Project	1	14	14
Seminar / Workshop	-	-	-
Oral Exams	-	-	-
Midterms	1	20	20
Final Exam	1	23	23
		Total	150

COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP

#	PC Sub	Program Competencies/Outcomes	* Contribution Level
#	PC Sub	Program Competencies/Outcomes	1	2	3	4	5
1	Engineering Knowledge: Knowledge of mathematics, science, basic engineering, computation, and related engineering discipline-specific topics; the ability to apply this knowledge to solve complex engineering problems.
	1	Mathematics
	2	Science				LO1
	3	Basic Engineering
	4	Computation				LO2
	5	Related engineering discipline-specific topics
	6	The ability to apply this knowledge to solve complex engineering problems
2	Problem Analysis: Ability to identify, formulate and analyze complex engineering problems using basic knowledge of science, mathematics and engineering, and considering the UN Sustainable Development Goals relevant to the problem being addressed.				LO3
3	Engineering Design: The ability to devise creative solutions to complex engineering problems; the ability to design complex systems, processes, devices or products to meet current and future needs, considering realistic constraints and conditions.
	1	Ability to design creative solutions to complex engineering problems			LO4 LO5
	2	Ability to design complex systems, processes, devices or products to meet current and future needs, considering realistic constraints and conditions			LO6
4	Use of Techniques and Tools: Ability to select and use appropriate techniques, resources, and modern engineering and computing tools, including estimation and modeling, for the analysis and solution of complex engineering problems, while recognizing their limitations.
5	Research and Investigation: Ability to use research methods to investigate complex engineering problems, including literature research, designing and conducting experiments, collecting data, and analyzing and interpreting results.
	1	Literature research for the study of complex engineering problems
	2	Designing experiments
	3	Ability to use research methods, including conducting experiments, collecting data. analyzing and interpreting results
6	Global Impact of Engineering Practices: Knowledge of the impacts of engineering practices on society, health and safety, economy, sustainability, and the environment, within the context of the UN Sustainable Development Goals; awareness of the legal implications of engineering solutions.
	1	Knowledge of the impacts of engineering practices on society, health and safety, economy, sustainability, and the environment, within the context of the UN Sustainable Development Goals
	2	Awareness of the legal implications of engineering solutions
7	Ethical Behavior: Acting in accordance with the principles of the engineering profession, knowledge about ethical responsibility; awareness of being impartial, without discrimination, and being inclusive of diversity.
	1	Acting in accordance with the principles of the engineering profession, knowledge about ethical responsibility ethical responsibility
	2	Awareness of being impartial and inclusive of diversity, without discriminating on any subject
8	Individual and Teamwork: Ability to work effectively, individually and as a team member or leader on interdisciplinary and multidisciplinary teams (face-to-face, remote or hybrid).
	1	Ability to work individually and within the discipline
	2	Ability to work effectively as a team member or leader in multidisciplinary teams (face-to-face, remote or hybrid)
9	Verbal and Written Communication: Taking into account the various differences of the target audience (such as education, language, profession) on technical issues.
	1	Ability to communicate verbally
	2	Ability to communicate effectively in writing
10	Project Management: Knowledge of business practices such as project management and economic feasibility analysis; awareness of entrepreneurship and innovation.
	1	Knowledge of business practices such as project management and economic feasibility analysis
	2	Awareness of entrepreneurship and innovation
11	Lifelong Learning: Lifelong learning skills that include being able to learn independently and continuously, adapting to new and developing technologies, and thinking questioningly about technological changes.