Department of Biomedical Engineering

BME 431 | Course Introduction and Application Information

Course Name

Micro-Electro-Mechanical Systems in Biomedical Applications

Code	Semester	Theory (hour/week)	Application/Lab (hour/week)	Local Credits	ECTS
BME 431	FALL	2	2	3	6

Prerequisites	None
Course Language	English
Course Type	ELECTIVE_COURSE
Course Level	First Cycle
Mode of Delivery	Face-To-Face
Teaching Methods and Techniques of the Course	Presentation Experiments Question and Answer Problem solving
National Occupational Classification Code	-
Course Coordinator	Dr. Öğr. Üyesi Yalın Kılıç
Course Lecturer(s)	Dr. Öğr. Üyesi Yalın Kılıç
Assistant(s)	-

Course Objectives

The purpose of this course is to introduce Micro Electro Mechanical Systems (MEMS), provide basic information about micro-electrical, -mechanical, -optical sensors, and demonstrate their applications in the design of biomedical devices and systems.

Learning Outcomes

The students who succeeded in this course;

Name	Description	PC Sub	* Contribution Level
Name	Description	PC Sub	1	2	3	4	5
LO1	will be able to introduce MEMS, bioMEMS, µTAS, and microfluidics.	1.5			X
LO2	can compare Micro/nano-sized sensors and converters	4			X
LO3	can explain MEMS and microfluidic structures, manufacturing and characterization processes.	3.2			X
LO4	will be able to discuss the design challenges in microstructures.	3.2			X
LO5	will be able to explain the working principles of MEMS in new biomedical applications.	1.5			X

Course Description

This course covers the structures of microfluidic and micro total analysis systems (µTAS), the basic definitions and principles of microelectrical, micromechanical, and microoptical sensors, as well as their design features and manufacturing technologies; MEMS, bioMEMS, and their biomedical applications, including Lab-on-a-Chip, implantable sensors, and drug delivery.

Related Sustainable Development Goals

Course Category	Core Courses
	Major Area Courses	X
	Supportive Courses
	Media and Managment Skills Courses
	Transferable Skill Courses

WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES

Week	Subjects	Required Materials	Learning Outcome
1	The Fundamentals of MEMS for Biomedical Applications	Folch, A. (2016). Introduction to bioMEMS. CRC press. (Ch.1) Bhansali, S., & Vasudev, A. (Eds.). (2012). MEMS for biomedical applications. Elsevier (Ch. 1)	LO1
2	Microfluidics: Fundamentals and Engineering Concepts	Hardt, S., & Schönfeld, F. (Eds.). (2007). Microfluidic technologies for miniaturized analysis systems. Springer Science & Business Media (Ch.1)	LO1
3	Molecular Sensors and Size Effect	"Zhang, J. X., & Hoshino, K. (2018). Molecular sensors and nanodevices: principles, designs and applications in biomedical engineering. Academic Press. (Ch.1,2)"	LO2
4	Micro-patterning in MEMS	Folch, A. (2016). Introduction to bioMEMS. CRC press. (Ch.2)	LO3
5	Electrical Converters	"Zhang, J. X., & Hoshino, K. (2018). Molecular sensors and nanodevices: principles, designs and applications in biomedical engineering. Academic Press. (Ch. 2,4)"	LO1
6	Optical Converters	"Zhang, J. X., & Hoshino, K. (2018). Molecular sensors and nanodevices: principles, designs and applications in biomedical engineering. Academic Press. (Ch.5)"	LO2
7	Mechanical Converters	"Zhang, J. X., & Hoshino, K. (2018). Molecular sensors and nanodevices: principles, designs and applications in biomedical engineering. Academic Press. (Ch. 6)"	LO2
8	Midterm Exam		-
9	Micropumps, Micro Stirring Devices, and Magnetic Particles	Hardt, S., & Schönfeld, F. (Eds.). (2007). Microfluidic technologies for miniaturized analysis systems. Springer Science & Business Media(Ch.2-6)	LO4
10	Nucleic Acid Amplification in Microsystems	Hardt, S., & Schönfeld, F. (Eds.). (2007). Microfluidic technologies for miniaturized analysis systems. Springer Science & Business Media (Ch.13)	LO5
11	Electrophoresis and Chromatography in Microstructures	Hardt, S., & Schönfeld, F. (Eds.). (2007). Microfluidic technologies for miniaturized analysis systems. Springer Science & Business Media (Ch.10,11)	LO3
12	Cytometry on Microfluidic Chips	Hardt, S., & Schönfeld, F. (Eds.). (2007). Microfluidic technologies for miniaturized analysis systems. Springer Science & Business Media (Ch.14)	LO5
13	MEMS for Tissue Engineering	Bhansali, S., & Vasudev, A. (Eds.). (2012). MEMS for biomedical applications. Elsevier (Ch. 7,8) Folch, A. (2016). Introduction to bioMEMS. CRC press (Ch.7)	LO5
14	Implantable Microdevices	"Zhang, J. X., & Hoshino, K. (2018). Molecular sensors and nanodevices: principles, designs and applications in biomedical engineering. Academic Press. (Ch.7)Folch, A. (2016). Introduction to bioMEMS. CRC press(Ch.13,14)"	LO3
15	Course Review		-
16	Yıl Sonu Sınavı		-

Course Notes/Textbooks

Folch A. (2016). Introduction to bioMEMS. CRC press. ISBN: 978-1439818398
Bhansali S. & Vasudev A. (Eds.). (2012). MEMS for biomedical applications. Elsevier. ISBN: 978-0-85709-129-1
Hardt S. & Schönfeld F. (Eds.). (2007). Microfluidic technologies for miniaturized analysis systems. Springer Science & Business Media.ISBN: 978-0-387-28597-9
Zhang J. X. & Hoshino K. (2018). Molecular sensors and nanodevices: principles designs and applications in biomedical engineering. Academic Press. ISBN: 978-1-4557-7631-3

Suggested Readings/Materials

EVALUATION SYSTEM

Semester Activities	Number	Weighting	LO1	LO2	LO3	LO4	LO5
Laboratory / Application	1	30	X	X	X	X	X
Midterm	1	30	X	X	X
Final Exam	1	40	X	X	X	X	X
Total	3	100

ECTS / WORKLOAD TABLE

Semester Activities	Number	Duration (Hours)	Workload
Participation	-	-	-
Theoretical Course Hours	16	2	32
Laboratory / Application Hours	16	2	32
Study Hours Out of Class	14	2	28
Field Work	-	-	-
Quizzes / Studio Critiques	-	-	-
Portfolio	-	-	-
Homework / Assignments	-	-	-
Presentation / Jury	-	-	-
Project	1	40	40
Seminar / Workshop	-	-	-
Oral Exams	-	-	-
Midterms	1	25	25
Final Exam	1	23	23
		Total	180

COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP

#	PC Sub	Program Competencies/Outcomes	* Contribution Level
#	PC Sub	Program Competencies/Outcomes	1	2	3	4	5
1	Engineering Knowledge: Knowledge of mathematics, science, basic engineering, computation, and related engineering discipline-specific topics; the ability to apply this knowledge to solve complex engineering problems.
	1	Mathematics
	2	Science
	3	Basic Engineering
	4	Computation
	5	Related engineering discipline-specific topics			LO1 LO5
	6	The ability to apply this knowledge to solve complex engineering problems
2	Problem Analysis: Ability to identify, formulate and analyze complex engineering problems using basic knowledge of science, mathematics and engineering, and considering the UN Sustainable Development Goals relevant to the problem being addressed.
3	Engineering Design: The ability to devise creative solutions to complex engineering problems; the ability to design complex systems, processes, devices or products to meet current and future needs, considering realistic constraints and conditions.
	1	Ability to design creative solutions to complex engineering problems
	2	Ability to design complex systems, processes, devices or products to meet current and future needs, considering realistic constraints and conditions			LO3 LO4
4	Use of Techniques and Tools: Ability to select and use appropriate techniques, resources, and modern engineering and computing tools, including estimation and modeling, for the analysis and solution of complex engineering problems, while recognizing their limitations.				LO2
5	Research and Investigation: Ability to use research methods to investigate complex engineering problems, including literature research, designing and conducting experiments, collecting data, and analyzing and interpreting results.
	1	Literature research for the study of complex engineering problems
	2	Designing experiments
	3	Ability to use research methods, including conducting experiments, collecting data. analyzing and interpreting results
6	Global Impact of Engineering Practices: Knowledge of the impacts of engineering practices on society, health and safety, economy, sustainability, and the environment, within the context of the UN Sustainable Development Goals; awareness of the legal implications of engineering solutions.
	1	Knowledge of the impacts of engineering practices on society, health and safety, economy, sustainability, and the environment, within the context of the UN Sustainable Development Goals
	2	Awareness of the legal implications of engineering solutions
7	Ethical Behavior: Acting in accordance with the principles of the engineering profession, knowledge about ethical responsibility; awareness of being impartial, without discrimination, and being inclusive of diversity.
	1	Acting in accordance with the principles of the engineering profession, knowledge about ethical responsibility ethical responsibility
	2	Awareness of being impartial and inclusive of diversity, without discriminating on any subject
8	Individual and Teamwork: Ability to work effectively, individually and as a team member or leader on interdisciplinary and multidisciplinary teams (face-to-face, remote or hybrid).
	1	Ability to work individually and within the discipline
	2	Ability to work effectively as a team member or leader in multidisciplinary teams (face-to-face, remote or hybrid)
9	Verbal and Written Communication: Taking into account the various differences of the target audience (such as education, language, profession) on technical issues.
	1	Ability to communicate verbally
	2	Ability to communicate effectively in writing
10	Project Management: Knowledge of business practices such as project management and economic feasibility analysis; awareness of entrepreneurship and innovation.
	1	Knowledge of business practices such as project management and economic feasibility analysis
	2	Awareness of entrepreneurship and innovation
11	Lifelong Learning: Lifelong learning skills that include being able to learn independently and continuously, adapting to new and developing technologies, and thinking questioningly about technological changes.