Department of Biomedical Engineering

BME 431 | Course Introduction and Application Information

Course Name

Micro-Electro-Mechanical Systems in Biomedical Applications

Code	Semester	Theory (hour/week)	Application/Lab (hour/week)	Local Credits	ECTS
BME 431	FALL	2	2	3	6

Prerequisites	None
Course Language	English
Course Type	ELECTIVE_COURSE
Course Level	First Cycle
Mode of Delivery	Face-To-Face
Teaching Methods and Techniques of the Course	Presentation Experiments Question and Answer Problem solving
National Occupational Classification Code	-
Course Coordinator	Dr. Öğr. Üyesi Yalın Kılıç
Course Lecturer(s)	Dr. Öğr. Üyesi Yalın Kılıç
Assistant(s)	-

Course Objectives

The purpose of this course is to introduce Micro Electro Mechanical Systems (MEMS), provide basic information about micro-electrical, -mechanical, -optical sensors, and demonstrate their applications in the design of biomedical devices and systems.

Learning Outcomes

The students who succeeded in this course;

Name	Description	PC Sub	* Contribution Level
Name	Description	PC Sub	1	2	3	4	5
LO1	will be able to introduce MEMS, bioMEMS, µTAS, and microfluidics.				X
LO2	can compare Micro/nano-sized sensors and converters				X
LO3	can explain MEMS and microfluidic structures, manufacturing and characterization processes.				X
LO4	will be able to discuss the design challenges in microstructures.				X
LO5	will be able to explain the working principles of MEMS in new biomedical applications.				X

Course Description

This course covers the structures of microfluidic and micro total analysis systems (µTAS), the basic definitions and principles of microelectrical, micromechanical, and microoptical sensors, as well as their design features and manufacturing technologies; MEMS, bioMEMS, and their biomedical applications, including Lab-on-a-Chip, implantable sensors, and drug delivery.

Related Sustainable Development Goals

Course Category	Core Courses
	Major Area Courses	X
	Supportive Courses
	Media and Managment Skills Courses
	Transferable Skill Courses

WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES

Week	Subjects	Required Materials	Learning Outcome
1	The Fundamentals of MEMS for Biomedical Applications	Folch, A. (2016). Introduction to bioMEMS. CRC press. (Ch.1) Bhansali, S., & Vasudev, A. (Eds.). (2012). MEMS for biomedical applications. Elsevier (Ch. 1)	LO1
2	Microfluidics: Fundamentals and Engineering Concepts	Hardt, S., & Schönfeld, F. (Eds.). (2007). Microfluidic technologies for miniaturized analysis systems. Springer Science & Business Media (Ch.1)	LO1
3	Molecular Sensors and Size Effect	"Zhang, J. X., & Hoshino, K. (2018). Molecular sensors and nanodevices: principles, designs and applications in biomedical engineering. Academic Press. (Ch.1,2)"	LO2
4	Micro-patterning in MEMS	Folch, A. (2016). Introduction to bioMEMS. CRC press. (Ch.2)	LO3
5	Electrical Converters	"Zhang, J. X., & Hoshino, K. (2018). Molecular sensors and nanodevices: principles, designs and applications in biomedical engineering. Academic Press. (Ch. 2,4)"	LO1
6	Optical Converters	"Zhang, J. X., & Hoshino, K. (2018). Molecular sensors and nanodevices: principles, designs and applications in biomedical engineering. Academic Press. (Ch.5)"	LO2
7	Mechanical Converters	"Zhang, J. X., & Hoshino, K. (2018). Molecular sensors and nanodevices: principles, designs and applications in biomedical engineering. Academic Press. (Ch. 6)"	LO2
8	Midterm Exam		-
9	Micropumps, Micro Stirring Devices, and Magnetic Particles	Hardt, S., & Schönfeld, F. (Eds.). (2007). Microfluidic technologies for miniaturized analysis systems. Springer Science & Business Media(Ch.2-6)	LO4
10	Nucleic Acid Amplification in Microsystems	Hardt, S., & Schönfeld, F. (Eds.). (2007). Microfluidic technologies for miniaturized analysis systems. Springer Science & Business Media (Ch.13)	LO5
11	Electrophoresis and Chromatography in Microstructures	Hardt, S., & Schönfeld, F. (Eds.). (2007). Microfluidic technologies for miniaturized analysis systems. Springer Science & Business Media (Ch.10,11)	LO3
12	Cytometry on Microfluidic Chips	Hardt, S., & Schönfeld, F. (Eds.). (2007). Microfluidic technologies for miniaturized analysis systems. Springer Science & Business Media (Ch.14)	LO5
13	MEMS for Tissue Engineering	Bhansali, S., & Vasudev, A. (Eds.). (2012). MEMS for biomedical applications. Elsevier (Ch. 7,8) Folch, A. (2016). Introduction to bioMEMS. CRC press (Ch.7)	LO5
14	Implantable Microdevices	"Zhang, J. X., & Hoshino, K. (2018). Molecular sensors and nanodevices: principles, designs and applications in biomedical engineering. Academic Press. (Ch.7)Folch, A. (2016). Introduction to bioMEMS. CRC press(Ch.13,14)"	LO3
15	Course Review		-
16	Yıl Sonu Sınavı		-

Course Notes/Textbooks

Folch A. (2016). Introduction to bioMEMS. CRC press. ISBN: 978-1439818398
Bhansali S. & Vasudev A. (Eds.). (2012). MEMS for biomedical applications. Elsevier. ISBN: 978-0-85709-129-1
Hardt S. & Schönfeld F. (Eds.). (2007). Microfluidic technologies for miniaturized analysis systems. Springer Science & Business Media.ISBN: 978-0-387-28597-9
Zhang J. X. & Hoshino K. (2018). Molecular sensors and nanodevices: principles designs and applications in biomedical engineering. Academic Press. ISBN: 978-1-4557-7631-3

Suggested Readings/Materials

EVALUATION SYSTEM

Semester Activities	Number	Weighting	LO1	LO2	LO3	LO4	LO5
Laboratory / Application	1	30	X	X	X	X	X
Midterm	1	30	X	X	X
Final Exam	1	40	X	X	X	X	X
Total	3	100

ECTS / WORKLOAD TABLE

Semester Activities	Number	Duration (Hours)	Workload
Participation	-	-	-
Theoretical Course Hours	16	2	32
Laboratory / Application Hours	16	2	32
Study Hours Out of Class	14	2	28
Field Work	-	-	-
Quizzes / Studio Critiques	-	-	-
Portfolio	-	-	-
Homework / Assignments	-	-	-
Presentation / Jury	-	-	-
Project	1	40	40
Seminar / Workshop	-	-	-
Oral Exams	-	-	-
Midterms	1	25	25
Final Exam	1	23	23
		Total	180