Department of Biomedical Engineering

BME 315 | Course Introduction and Application Information

Course Name

Molecular Biophysics

Code	Semester	Theory (hour/week)	Application/Lab (hour/week)	Local Credits	ECTS
BME 315	FALL	3	0	3	5

Prerequisites	GBE 100 To succeed (To get a grade of at least DD)
Course Language	English
Course Type	ELECTIVE_COURSE
Course Level	First Cycle
Mode of Delivery	Face-To-Face
Teaching Methods and Techniques of the Course	-
National Occupational Classification Code	-
Course Coordinator	Doç. Dr. Osman Doluca
Course Lecturer(s)	Doç. Dr. Osman Doluca
Assistant(s)	-

Course Objectives

The aim of this course is to discuss the theories and applications of biophysics in the fields of nanomedicine and biomedical sciences. Biophysics is a promising interdisciplinary field that combines the principles and concepts of physics, biology, chemistry, biochemistry, medicine, and engineering. The objective of this course is to provide a comprehensive introduction to biological systems at the molecular and subcellular levels, with an emphasis on electrical and dynamic behavior. Additionally, the course aims to discuss fundamental theories in biomedicine and their applications through current examples.

Learning Outcomes

The students who succeeded in this course;

Name	Description	PC Sub	* Contribution Level
Name	Description	PC Sub	1	2	3	4	5
LO1	Will be able to explain the terminology related to biophysics,			X
LO2	Will be able to identify biological structures and biomedical samples,				X
LO3	Will be able to describe the radiation function, the interaction of light with matter and biophysical methods,				X
LO4	Will be able to explain the applicability of biophysical principles to the biomedical field,			X
LO5	Will be able to discuss new and cutting-edge technologies in the field of biomedicine and nanobiomedicine.			X

Course Description

This course covers the binding interactions of biomolecules/biopolymers, structural-functional and dynamic properties of biomolecules (nucleic acids, proteins, lipids, etc.), enzyme mechanisms, cell membrane dynamics, membrane proteins, transport, physics of neurons, thermodynamics, bioenergetics, radiation processes, biomedical spectroscopy, infrared spectroscopy, and new approaches in nanobiomedicine and biomedical fields.

Related Sustainable Development Goals

Course Category	Core Courses
	Major Area Courses	X
	Supportive Courses
	Media and Managment Skills Courses
	Transferable Skill Courses

WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES

Week	Subjects	Required Materials	Learning Outcome
1	Molecular forces in biological structures: interactions, bonding, force fields, energy functions	Chapter 2, Jackson, M. B. (2006). Molecular and Cellular Biophysics. Cambridge University Press. ISBN 052162441	LO1
2	Organelles and molecular structure of cells	Chapter 1, Abeles, R. H., Frey, P. A., & Jencks, W. P. (1992). Biochemistry. Jones & Bartlett Publishers. ISBN-13 978-0867202120	LO2
3	Structural and functional properties of biomolecules - nucleic acids	Chapter 7,12,19, Abeles, R. H., Frey, P. A., & Jencks, W. P. (1992). Biochemistry. Jones & Bartlett Publishers. ISBN-13 978-0867202120	LO2
4	Structural and functional properties of biomolecules - proteins	Chapter 7,12,19, Abeles, R. H., Frey, P. A., & Jencks, W. P. (1992). Biochemistry. Jones & Bartlett Publishers. ISBN-13 978-0867202120	LO2
5	Enzyme mechanisms, Enzyme reactions and kinetics	Chapter 10, Jackson, M. B. (2006). Molecular and Cellular Biophysics. Cambridge University Press. ISBN 052162441	LO2
6	Thermodynamics, bioenergetics, ionization of biological molecules	Chapter 13, Jackson, M. B. (2006). Molecular and Cellular Biophysics. Cambridge University Press. ISBN 052162441	LO3
7	Ion permeability and membrane potential, neuron physics, nerve signals, action potential	Chapter 13, Jackson, M. B. (2006). Molecular and Cellular Biophysics. Cambridge University Press. ISBN 052162441	LO3
8	Midterm		-
9	Interaction of IR radiation with biomolecules, vibration modes; Infrared Spectroscopy in Biomedical field	Chapter 12, Atkins, P., De Paula, J., & Keeler, J. (2022). Atkins’ physical chemistry. Oxford University Press. ISBN 9780198847816	LO4
10	Radiation processes (emission, scattering, absorption) and properties of light; UV-Vis Spectroscopy, CD Spectroscopy, Fluorescence Spectroscopy, and Biomedical applications - II	Chapter 12, Atkins, P., De Paula, J., & Keeler, J. (2022). Atkins’ physical chemistry. Oxford University Press. ISBN 9780198847816	LO4
11	Radiation processes (emission, scattering, absorption) and properties of light; UV-Vis Spectroscopy, CD Spectroscopy, Fluorescence Spectroscopy, and Biomedical applications - II	Chapter 12, Atkins, P., De Paula, J., & Keeler, J. (2022). Atkins’ physical chemistry. Oxford University Press. ISBN 9780198847816	LO4
12	X-ray crystallography, diffraction; Drug/ligand interactions	Lecture notes	LO5
13	Nanobiomedicine, Drug delivery, Characterization	Lecture notes	LO5
14	Studies from recent literature on the application of biomedical and biophysical techniques to biological samples	Lecture notes	LO5
15	Review	Lecture notes	-
16	Final Exam		-

Course Notes/Textbooks	Jackson M. B. (2006). Molecular and Cellular Biophysics. Cambridge University Press. ISBN 052162441 Atkins P. De Paula J. & Keeler J. (2022). Atkins’ physical chemistry. Oxford University Press. ISBN 9780198847816 Abeles R. H. Frey P. A. & Jencks W. P. (1992). Biochemistry. Jones & Bartlett Publishers. ISBN-13 978-0867202120
Suggested Readings/Materials	-

EVALUATION SYSTEM

Semester Activities	Number	Weighting	LO1	LO2	LO3	LO4	LO5
Quizzes / Studio Critiques	1	30		X	X	X	X
Midterm	1	30	X	X	X
Final Exam	1	40	X	X	X	X	X
Total	3	100

ECTS / WORKLOAD TABLE

Semester Activities	Number	Duration (Hours)	Workload
Participation	-	-	-
Theoretical Course Hours	16	3	48
Laboratory / Application Hours	-	-	-
Study Hours Out of Class	14	2	28
Field Work	-	-	-
Quizzes / Studio Critiques	1	15	15
Portfolio	-	-	-
Homework / Assignments	-	-	-
Presentation / Jury	-	-	-
Project	-	-	-
Seminar / Workshop	-	-	-
Oral Exams	-	-	-
Midterms	1	27	27
Final Exam	1	32	32
		Total	150